Therapeutic modes of action

How Migraine Escape® works to relieve pain and prevent migraine

Migraine Escape Mode of Action Anti-inflammation COX-2

Anti-inflammation

COX-2 mechanism

Inflammation plays a central role in almost all pain. In migraine, activation of trigeminal nerves as part of the inflammatory response releases chemicals that are strongly associated with migraine pain, such as calcitonin gene-related peptide (CGRP) and cyclooxygenase-2 (COX-2).

University of Pennsylvania and University of Illinois research shows that the compounds [10]-gingerol, [8]-shogaol and [10]-shogaol in Migraine Escape® inhibit COX-2 in the same way as NSAID drugs, thereby suppressing the inflammatory process and pain response.1, 2

Anti-inflammation

CGRP mechanism

CGRP is now recognised as perhaps the most important pain-causing chemical released during migraine. That is why the newest migraine drugs are all targeting the chemical as their mode of action.3

They started hitting the market in 2018 at a whopping cost of $6,000+ a year. Meanwhile, George Mason University scientists show that phytochemicals contained within Migraine Escape® have potent CGRP-suppressant properties, giving migraine sufferers cutting-edge pain relief at a fraction of the cost.4

Migraine Escape Mode of Action Anti-inflammation CGRP
Migraine Escape Mode of Action Anti-nociception

Anti-nociception

Migraines are associated with increased prostaglandin output and heightened sensitivity of the nociceptors, which can be interpreted as a greater sensitivity to pain.

University of Sydney research shows that gingerols, a key compound group in Migraine Escape®, inhibit the VR1 pain receptors, which translates into reduced sensitivity to pain.5

Anti-oxidation

Excess levels of oxidants, toxins and free radicals (e.g. caused by stress, diet, hormones, environmental toxins etc) leads to impaired cellular function and enhanced inflammation, creating conditions for a migraine attack and intensifying the pain response.

Key phytochemicals in Migraine Escape®, such as gingerol compounds and [6]-shogaol, possess antioxidant properties due to high phenolic content. They flush and cleanse the body of toxins and free radicals, reducing the chemical imbalance at the heart of migraine. The result is a reduction in both the frequency and intensity of migraine attacks.6

Migraine Escape Mode of Action Oxidative Stress
Migraine Escape Mode of Action Neuroprotection

Neuroprotection

Years of migraine pain and inflammation leads to cell damage and the breaking down of nerve plasticity in the brain. This simply makes us even more susceptible to migraine. It becomes a very vicious circle.

The phytochemical [6]-shogaol in Migraine Escape® is shown to possess neuroprotective effects through suppression of microglial cell activation. Regular use can help to rebuild the plasticity of nerves in the brain, improving your durability against migraine and leading to fewer migraine attacks over time.7

Anti-emesis

Migraines and emesis (nausea) are closely linked, with nausea a common prodromal symptom that precedes the pain of a migraine attack.

Migraine Escape® possesses a number of phytochemicals - such as [6]-gingerol & zingerone - that inhibit serotonin (5-HT(3)) and dopamine (D2R) receptors, chemicals that trigger nausea. As a result, Migraine Escape® users who are particularly sensitive to smell or nausea find that it can control their nausea, which is enough to extinguish an oncoming migraine attack.8, 9

Migraine Escape Mode of Action Anti-emetic
Scientific references

1. Van Breemen RB, Tao Y, Li W. Cyclooxygenase-2 inhibitors in ginger (Zingiber officinale). Fitoterapia. 2011 January ; 82(1): 38–43.

2. Ricciotti E, FitzGerald GA. Prostaglandins and Inflammation. Arterioscler Thromb Vasc Biol. 2011;31:986-1000.

3. Durham, Paul. Inhibition of Calcitonin Gene-Related Peptide Function: A Promising Strategy for Treating Migraine. Headache. 2008 Sep. 48(8): 1269-75. doi: 10.1111/j.1526-4610.2008.01215.x.

4. Slavin M, Bourguignon J, Jackson K, Orciga MA. Impact of Food Components on in vitro Calcitonin Gene-Related Peptide Secretion - A Potential Mechanism for Dietary Influence on Migraine. Nutrients 2016, 8, 406.

5. Dedov VN et al. Gingerols: a novel class of vanilloid receptor (VR1) agonists. Br J Pharmacol. 2002 Nov; 137(6): 793-798.

6. Dugasani S et al. Comparative antioxidant and anti-inflammatory effects of [6]-gingerol, [8]-gingerol, [10]-gingerol and [6]-shogaol. J Ethnopharmacol. 2010 Feb 3; 127(2): 515-20.

7. Ha SK et al. 6-Shogaol, a ginger product, modulates neuroinflammation: a new approach to neuroprotection. Neuropharmacology. 2012 Aug; 63(2): 211-23.

8. Lete I & Allué J. The Effectiveness of Ginger in the Prevention of Nausea and Vomiting during Pregnancy and Chemotherapy. Integr Med Insights. 2016; 11: 11-17.

9. Dedov VN et al. Gingerols: a novel class of vanilloid receptor (VR1) agonists. Br J Pharmacol. 2002 Nov; 137(6): 793-798.